Using a novel class of effectors to probe fundamental mechanisms of intracellular disease.

使用一类新型效应器来探索细胞内疾病的基本机制。

• 批准号: 389779
• 负责人: Ensminger Alexander W
• 金额: $ 69.66万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=389779&lang=en
• 关键词: Bacterial Pathogenesis; Fundamental Mechanisms Of Microbial Disease; Host-Pathogen Interactions; Legionella; Metaeffectors; Microbial Systems Biology; Molecular Microbiology; Structure-Function Studies; Translocated Effectors; Ubiquitination

The incidence of the severe pneumonia that Legionella causes (Legionnaires' disease) is inexplicably on the rise - and deadly outbreaks have occurred in Toronto, Quebec City, and Calgary. Legionella can be isolated from the water systems of approximately

军团菌引起的严重肺炎（军团病）的发病率令人费解地在上升--多伦多、魁北克市和卡尔加里都发生了致命的疫情。军团菌可以从大约