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Noradrenergic control of vulnerability to chronic stress: novel mechanisms and targets

Noradrenergic control of vulnerability to chronic stress: novel mechanisms and targets
去甲肾上腺素能控制慢性应激的脆弱性：新机制和目标
批准号：
401510
负责人：
Giros Bruno J
金额：
$64.37万
依托单位：
CIUSSS de l'Ouest-de-l'Ile-de-Montral-Douglas Hospital
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-03-01 至 2024-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401510&lang=en
关键词：
Antidepressant Chronic Social Defeat Chronic Stress Depression Dopamine In Vivo Calcium Imaging Noradrenaline Noradrenergic Receptors Resiliency

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英文摘要
Depressive disorders are common and debilitating conditions affecting about 20% of people in North America within their lifetime. Despite some effective treatments, roughly one third of depressive patients are treatment-resistant. It is well known that
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Understanding the complexity of dopamine transmission: Specific role of the neurons co-expressing D1 and D2 receptors.
A pharmacological approach to reduce cognitive deficits in psychosis: Targeting of the dopamine D1 receptors.
CRC Tier 1
  • 批准号：
    314126
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2013
  • 负责人：
    Giros Bruno J
  • 依托单位：
    McGill University
Regulation of the Dopamine Transporter functional activity. Identification of new targets.