Corticospinal descending modulation of spinal sensory transduction in chronic pain

慢性疼痛中脊髓感觉转导的皮质脊髓下行调节

• 批准号: 401279
• 负责人: Zhuo Min
• 金额: $ 62.7万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401279&lang=en
• 关键词: Anterior Cingulate Cortex; Descending Facilitation; Descending Inhibition; Glutamatergic Synapse; Inflammatory Pain; Neurophathic Pain; Optogenetic Stimulation; Rats; Spinal Dorsal Horn; Whole Cell Patch Clamp

Chronic pain is a severe medical condition that causes long-term suffering for patients, with no effective treatment available. This proposal aims to understand how the brain, or cortex, may affect pain transmission at the level of the spinal cord, a key

慢性疼痛是一种严重的医疗条件，导致长期痛苦的患者，没有有效的治疗。这项提议旨在了解大脑或皮层如何影响脊髓水平的疼痛传递，这是一个关键。