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Ectopic reactivation of normally silenced germ cell programs contributes to genomic instability, carcinogenesis and cancer progression in Cutaneous T-Cell Lymphomas (CTCL).

Ectopic reactivation of normally silenced germ cell programs contributes to genomic instability, carcinogenesis and cancer progression in Cutaneous T-Cell Lymphomas (CTCL).
正常沉默的生殖细胞程序的异位重新激活会导致皮肤 T 细胞淋巴瘤 (CTCL) 的基因组不稳定、致癌和癌症进展。
批准号：
414864
负责人：
Litvinov Ivan V
金额：
$1.82万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2020-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=414864&lang=en
关键词：
Cancer/Testis Genes Cutaneous T -Cell Lymphoma Dermatology Diagnostic Markers Genomic Instability Meiomitosis Mucosis Fungoides Prognostic Markers Retrotransposons Sezary Syndrome

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英文摘要
Cutaneous T-Cell Lymphoma (CTCL) is the most common lymphoma of the skin. Despite recent advances, this lymphoma remains difficult to diagnose (time to diagnosis ~6 years) because it mimics other common skin rashes such as eczema and psoriasis. It is also
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Evidence-Based Dialogue to Promote Sun Protection, Foster a Community of Concern and Increase Awareness for Skin Cancers in Canada.
Studying sun protection practices and promoting sun awareness in Canadian youth in order to decrease incidence of melanoma and other skin cancers in the adulthood.
SunFit Project: skin cancer prevention through behavioral risk factor modification targeting sun and ultraviolet exposure practices using sex/gender and community-specific approaches
  • 批准号：
    460542
  • 项目类别：
    Operating Grants
  • 资助金额：
    $7.11万
  • 财政年份：
    2021
  • 负责人：
    Litvinov Ivan V
  • 依托单位：
    McGill University
Studying the biology and clinical utility of aberrantly expressed cancer testis, and embryonic stem cell genes for the treatment of advanced/recurrent NMSCs.
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