Analyses of the molecular roles of Tubby, the founding member of the developmentally important TUB Domain protein family

对发育重要的 TUB 结构域蛋白家族的创始成员 Tubby 的分子作用进行分析

• 批准号: 410209
• 负责人: Cordes Sabine P
• 金额: $ 73.29万
• 依托单位: Lunenfeld-Tanenbaum Research Institute (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=410209&lang=en
• 关键词: Cilia; Hypothalamic Appetite Regulation; Mouse Genetics; Neurodevelopment; Neuropeptide Y; Protein Trafficking; Retinitis Pigmentosa; Rna Biology; Rnaseq

In mice and humans, mutations in the Tubby (Tub) gene cause maturity-onset obesity, insulin resistance, and retinitis pigmentosa. Tub and the related Tub-like proteins Tulp1, 2, 3 and 4 all contain a novel nucleic acid binding domain - the TUB domain. Mut

在小鼠和人类中，Tubby（Tub）基因的突变导致成熟型肥胖、胰岛素抵抗和视网膜色素变性。Tub和相关的Tub样蛋白Tulp 1、2、3和4都含有一个新的核酸结合结构域-TUB结构域。Mut