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Characterization of epigenetic dysregulation in clonal myeloid cell populations with somatic DNMT3A and TET2 mutations in pulmonary arterial hypertension.

Characterization of epigenetic dysregulation in clonal myeloid cell populations with somatic DNMT3A and TET2 mutations in pulmonary arterial hypertension.
肺动脉高压中体细胞 DNMT3A 和 TET2 突变的克隆骨髓细胞群表观遗传失调的特征。
批准号：
415413
负责人：
Vlasschaert Caitlyn
金额：
$7.65万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-11-01 至 2022-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=415413&lang=en
关键词：
Clonal Hematopoeisis Of Indeterminate Potential Dna Methylation Epigenetics Inflammation Pulmonary Arterial Hypertension

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英文摘要
Pulmonary arterial hypertension (PAH) is an incurable disease with a 50% 5-year mortality rate. In PAH, the walls of arteries in the lung become inflamed and thicken, which effectively means less blood can flow through to become oxygenated. The increased
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Clonal hematopoiesis in diabetes and kidney disease
The investigation of a potential regulator of spermatogonial stem cell pool size for its application in oncofertility
  • 批准号：
    311680
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2013
  • 负责人：
    Vlasschaert Caitlyn
  • 依托单位：
    University of Ottawa
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