Calcium-activated proteases in health and disease

钙激活蛋白酶在健康和疾病中的作用

• 批准号: 189101
• 负责人: Davies Peter L
• 金额: $ 69.3万
• 依托单位: Queen's University (Kingston, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-09-01 至 2014-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=189101&lang=en
• 关键词: Calcium; Calpains/Proteases; Inhibitors; Molecular Modeling; Protein Engineering; X-Ray Crystallography

Calpains are enzymes in every cell of our body that are regulated by calcium ions to cut other proteins in a selective and highly controlled way. This is a normal and essential process required for cell functions like motility, cell division, and developm

钙蛋白酶是我们体内每个细胞中的酶，受钙离子的调节，以选择性和高度受控的方式切割其他蛋白质。这是细胞运动、细胞分裂和发育等功能所必需的正常和必要的过程