Assessing the Impact of Genetic Modifications on Chimeric Antigen Receptor (CAR) T-Cell Proliferation Capacity and Persistence

评估基因修饰对嵌合抗原受体 (CAR) T 细胞增殖能力和持久性的影响

• 批准号: 428962
• 负责人: Maru Bruktawit
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428962&lang=en
• 关键词: Acute Lymphoblastic Leukemia; Adaptive T-Cell Expansion And Persistance; Cancer Research; Chimeric Antigen Receptor (Car) T-Cells; Cyclophosphamide Resistance; Genetic Engineering; Immunotherapy; Lymphodepletion; Synthetic Biology

"Cancer is the leading cause of death across the globe. There is substantial research being done to develop a curative treatment with minimal side effects. However, these efforts are challenged by the complexity of cancer cells. They have mechanisms in pl

“癌症是地球仪的主要死因。目前正在进行大量研究，以开发一种副作用最小的治愈性治疗方法。然而，这些努力受到癌细胞复杂性的挑战。他们有一种机制，