Unraveling Roles for Bile Acids in Health and Disease Using Human Stem Cell Derived Cholangiocytes

利用人类干细胞衍生的胆管细胞揭示胆汁酸在健康和疾病中的作用

• 批准号: 434198
• 负责人: Kamath Binita M
• 金额: $ 60.75万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=434198&lang=en
• 关键词: Bile Acid; Cholangioctye; Cholestasis; Human Induced Pluripotent Stem Cell

Bile duct disorders represent a significant disease burden and risk of death. Two bile duct diseases, biliary atresia (BA) and primary sclerosing cholangitis (PSC), have no therapies and are principal indications for liver transplantation in children and

胆管疾病是一种重大的疾病负担和死亡风险。两种胆道疾病，胆道闭锁(BA)和原发性硬化性胆管炎(PSC)，没有治疗方法，是儿童肝移植的主要适应症