Characterizing the role of the endothelial transcription factor ERG in the development of abdominal aortic aneurysms: Towards novel therapeutic targets

表征内皮转录因子 ERG 在腹主动脉瘤发展中的作用：寻找新的治疗靶点

• 批准号: 440153
• 负责人: Botts Steven R
• 金额: $ 7.65万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-11-01 至 2023-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=440153&lang=en
• 关键词: Abdominal Aortic Aneurysm; E26 Transformation-Specific Related Gene; Endothelial Cell-Macrophage Communication; Macrophage Polarization; Vascular Inflammation

The aorta is the largest blood vessel in the human body and is responsible for carrying high pressure blood away from the heart and towards the abdomen. In approximately 1 in 100 older adults, the wall of the aorta weakens and expands over time, producing

主动脉是人体中最大的血管，负责将高压血液从心脏运送到腹部。在大约1/100的老年人中，主动脉壁随着时间的推移而减弱和扩张，