Characterization of the clonal dynamics of HIV-specific T-cell repertoire from a phase 2b/3 HIV-vaccine efficacy trial

2b/3 期 HIV 疫苗功效试验中 HIV 特异性 T 细胞库的克隆动态特征

• 批准号: 477372
• 负责人: Xu Guoyue
• 金额: $ 7.65万
• 依托单位: Fred Hutchinson Cancer Center (Seattle)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477372&lang=en
• 关键词: Bulk And Single Cell T-Cell Receptor Sequencing; Hiv & Vaccine-Efficacy Trial; Systems Immunology; T-Cell Clonal Dynamics; T-Cell Repertoire

With an estimated 1.5 million new cases and 650 000 deaths globally in 2021, human immunodeficiency virus (HIV) infection is a major contributor to the global burden of disease and causes significant burden on healthcare systems in low-resource communitie

据估计，2021年全球将有150万新发病例和65万例死亡，人类免疫缺陷病毒（HIV）感染是全球疾病负担的主要贡献者，并对资源匮乏社区的医疗保健系统造成重大负担。