Investigation of the impact of glioblastoma on microglial protein signature, metabolism, function and ultrastructure in males and females

研究胶质母细胞瘤对男性和女性小胶质细胞蛋白特征、代谢、功能和超微结构的影响

• 批准号: 473547
• 负责人: St-Pierre Marie-Kim
• 金额: $ 10.93万
• 依托单位: Karolinska Institutet (Stockholm)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=473547&lang=en
• 关键词: Glioblastoma; Metabolism; Microglia; Nervous System; Neuroimmunology; Sex Differences

Microglia, resident brain immune cells, are crucial in maintaining brain equilibrium throughout the lifespan. Their functions include surveying their environment to eat and destroy pathogens (by phagocytosis). Microglia are key players in the pathogenesis

小胶质细胞是常驻的大脑免疫细胞，在整个生命周期中维持大脑平衡至关重要。它们的功能包括调查它们的环境来吃和消灭病原体（通过吞噬作用）。小胶质细胞在发病机制中起关键作用