Delineating the functional role of the amyloid precursor protein's copper binding domain

描述淀粉样蛋白前体蛋白铜结合域的功能作用

• 批准号: DP1096225
• 负责人: Prof Roberto Cappai
• 金额: $ 20.9万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1096225
• 关键词: Delineating; functional; role; amyloid; precursor

This study will define how the interaction between copper and the amyloid precursor protein (APP) molecule regulates copper homeostasis and APP metabolism. Since copper homeostasis is tightly regulated and vital for normal cellular function, understanding the regulation copper homeostasis is important for basic biology. Moreover, APP is directly involved in causing Alzheimer's disease and therefore understanding the interaction between APP and copper has potential benefits for community health by combating aging and Alzheimer's disease.

本研究将明确铜和淀粉样前体蛋白（APP）分子之间的相互作用如何调节铜稳态和APP代谢。由于铜稳态受到严格的调节，对正常的细胞功能至关重要，因此了解铜稳态的调节对于基础生物学非常重要。此外，APP直接参与引起阿尔茨海默病，因此了解APP和铜之间的相互作用对社区健康有潜在的好处，可以对抗衰老和阿尔茨海默病。