Delineating the functional role of the amyloid precursor protein's copper binding domain

点击翻译按钮获取中文摘要

This study will define how the interaction between copper and the amyloid precursor protein (APP) molecule regulates copper homeostasis and APP metabolism. Since copper homeostasis is tightly regulated and vital for normal cellular function, understanding the regulation copper homeostasis is important for basic biology. Moreover, APP is directly involved in causing Alzheimer's disease and therefore understanding the interaction between APP and copper has potential benefits for community health by combating aging and Alzheimer's disease.