Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
批准号:
480732
负责人:
Sun Rui
金额:
$0.11万
依托单位:
依托单位国家:
加拿大
项目类别:
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-01-01 至 2024-01-01
中文摘要
尽管已知TH1和TH2免疫反应具有相互拮抗的性质,但前者在哮喘发病机制中的作用尚不清楚。我们采用了卵清蛋白(OVA)诱导的布朗-挪威(BN)大鼠哮喘模型,并联合应用多聚糖
英文摘要
Although there is a known mutually antagonistic nature of TH1 and TH2 immune responses, the role of the former in asthma pathogenesis is unclear. We adopted an ovalbumin (OVA)-induced Brown-Norway (BN) rat “asthma” model with the co-administration of poly
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