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Inhibiting Thrombopoietin Receptor (TPO-R) Signaling as a Novel Approach to Target TET2 Mutation-Driven Clonal Hematopoiesis

Inhibiting Thrombopoietin Receptor (TPO-R) Signaling as a Novel Approach to Target TET2 Mutation-Driven Clonal Hematopoiesis
抑制血小板生成素受体 (TPO-R) 信号传导作为靶向 TET2 突变驱动的克隆造血的新方法
批准号:
483332
负责人:
Chan Steven M
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-03-01 至 2024-03-01

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中文摘要
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英文摘要
Clonal Hematopoiesis of Indeterminate Potential (CHIP) refers to the presence of blood cells carrying mutations associated with leukemia in individuals without evidence of a blood disorder. Individuals with CHIP are at a substantially higher risk of devel
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Inhibiting Thrombopoietin Receptor (TPO-R) Signaling as a Novel Approach to Target TET2 Mutation-Driven Clonal Hematopoiesis
  • 批准号:
    489650
  • 项目类别:
    Operating Grants
  • 资助金额:
    $29.82万
  • 财政年份:
    2023
  • 负责人:
    Chan Steven M
  • 依托单位:
Role of Thrombopoietin Receptor (TPO-R) Signaling in TET2 Mutation-Driven Clonal Hematopoiesis
  • 批准号:
    472513
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Chan Steven M
  • 依托单位:
Repurposing Metformin to Target TET2 Mutation Driven Clonal Hematopoiesis and Malignant Transformation
  • 批准号:
    434508
  • 项目类别:
    Operating Grants
  • 资助金额:
    $41.8万
  • 财政年份:
    2020
  • 负责人:
    Chan Steven M
  • 依托单位:
PINK1 Inhibition as a Novel Therapeutic Strategy to Target Acute Myeloid Leukemia Stem Cells
  • 批准号:
    380799
  • 项目类别:
    Operating Grants
  • 资助金额:
    $25.36万
  • 财政年份:
    2018
  • 负责人:
    Chan Steven M
  • 依托单位:
海外基金