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A paradigm shift in understanding Hunner lesion-interstitial cystitis/bladder pain syndrome: examining autoimmunity as a driver of disease and targeting B cells as a novel therapeutic opportunity

A paradigm shift in understanding Hunner lesion-interstitial cystitis/bladder pain syndrome: examining autoimmunity as a driver of disease and targeting B cells as a novel therapeutic opportunity
理解 Hunner 病变-间质性膀胱炎/膀胱疼痛综合征的范式转变：检查自身免疫作为疾病的驱动因素并将 B 细胞作为一种新的治疗机会
批准号：
486970
负责人：
Cotechini Tiziana
金额：
$10.93万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
已结题
起止时间：
2023-07-01 至 2024-07-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486970&lang=en
关键词：
Antibody Autoimmunity B Cells Hunner Lesion Inflammation Interstitial Cystitis/Bladder Pain Syndrome Population-Based Study Pre-Clinical Model Tertiary Lymphoid Structure

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英文摘要
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a challenging chronic pain condition that disproportionally affects women. Approximately 10-20% of patients with IC/BPS suffer from a more severe form of the disease due to the presence of inflammato
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