Molecular dissection of malaria parasite motility and host-cell invasion across the lifecycle

疟疾寄生虫整个生命周期运动和宿主细胞入侵的分子解剖

• 批准号: FT100100112
• 负责人: Prof Jake Baum
• 金额: $ 35.18万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-10-25
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT100100112
• 关键词: Molecular; dissection; malaria; parasite; motility

Malaria parasites move in a unique way, gliding across cell surfaces and infecting host cells using a unique molecular motor. This research aims to understand the molecular mechanics behind parasite movement and use this to develop novel drugs that might throw a spanner in the parasite motor, blocking movement and thereby preventing malaria disease.

疟疾寄生虫以一种独特的方式移动，在细胞表面滑行，并使用独特的分子马达感染宿主细胞。这项研究旨在了解寄生虫运动背后的分子力学，并利用这一点来开发新型药物，这些药物可能会向寄生虫的马达抛出扳手，阻止寄生虫的运动，从而预防疟疾。