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"Investigating the Regulatory Role of Cerebral Cavernous Malformation Gene, CCM3 in Notch-Driven Tumour Formation with Caenorhabditis elegans"

"Investigating the Regulatory Role of Cerebral Cavernous Malformation Gene, CCM3 in Notch-Driven Tumour Formation with Caenorhabditis elegans"
“研究脑海绵状血管瘤基因 CCM3 在秀丽隐杆线虫缺口驱动肿瘤形成中的调节作用”
批准号：
367159
负责人：
Jiang Yan Q
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-12-01 至 2017-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367159&lang=en
关键词：
Caenorhabditis Elegans Ccm3/Pdcd10 Cerebral Cavernous Malformations Genetic Interactions Germ-Line Human Disease Model Notch Signalling Stem Cell Hyperproliferation Tumour Formation Whole Organism Model

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中文摘要
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英文摘要
Cerebral cavernous malformation (CCM) is a prevalent neurovascular disease marked by malformations of the cranial vasculature. CCM3/PDCD10 is one of the three genes whose loss-of-function lead to familial forms of CCM. Molecular mechanisms by which CCM
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