"Investigating the Regulatory Role of Cerebral Cavernous Malformation Gene, CCM3 in Notch-Driven Tumour Formation with Caenorhabditis elegans"

“研究脑海绵状血管瘤基因 CCM3 在秀丽隐杆线虫缺口驱动肿瘤形成中的调节作用”

• 批准号: 367159
• 负责人: Jiang Yan Q
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-12-01 至 2017-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367159&lang=en
• 关键词: Caenorhabditis Elegans; Ccm3/Pdcd10; Cerebral Cavernous Malformations; Genetic Interactions; Germ-Line; Human Disease Model; Notch Signalling; Stem Cell Hyperproliferation; Tumour Formation; Whole Organism Model

Cerebral cavernous malformation (CCM) is a prevalent neurovascular disease marked by malformations of the cranial vasculature. CCM3/PDCD10 is one of the three genes whose loss-of-function lead to familial forms of CCM. Molecular mechanisms by which CCM

脑海绵状血管病（CCM）是一种以颅内血管畸形为特征的常见神经血管疾病。CCM3/PDCD10是三个功能缺失导致家族性CCM的基因之一。CCM的分子机制