Impact of a tachycardia-associated mutation in the sinoatrial pacemaker channel on its regulation by cyclic AMP

窦房起搏器通道中与心动过速相关的突变对其环磷酸腺苷调节的影响

• 批准号: 429086
• 负责人: Xia Joanna
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=429086&lang=en
• 关键词: C-Terminus; Camp Binding Affinity; Channel Gating; Funny Current; Hcn Isoform-4 (Hcn4); Inappropriate Sinus Tachycardia; Isothermal Titration Calorimetry; Mathematical Modelling; Receptor Allosteric Alterations; Single Amino Acid Mutation

"Our heart rate is controlled by a group of cells in the heart, which contains a protein that makes up the pacemaker channel. When pacemaker channel opens, positive ions flow into the cell, resulting in electrical impulses that enable the heart to beat. D

“我们的心率是由心脏中的一组细胞控制的，其中含有一种构成起搏器通道的蛋白质。当起搏器通道打开时，正离子流入细胞，产生电脉冲，使心脏跳动。D