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Impact of a tachycardia-associated mutation in the sinoatrial pacemaker channel on its regulation by cyclic AMP

Impact of a tachycardia-associated mutation in the sinoatrial pacemaker channel on its regulation by cyclic AMP
窦房起搏器通道中与心动过速相关的突变对其环磷酸腺苷调节的影响
批准号：
429086
负责人：
Xia Joanna
金额：
$1.27万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-12-01 至 2020-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=429086&lang=en
关键词：
C-Terminus Camp Binding Affinity Channel Gating Funny Current Hcn Isoform-4 (Hcn4) Inappropriate Sinus Tachycardia Isothermal Titration Calorimetry Mathematical Modelling Receptor Allosteric Alterations Single Amino Acid Mutation

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中文摘要
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英文摘要
"Our heart rate is controlled by a group of cells in the heart, which contains a protein that makes up the pacemaker channel. When pacemaker channel opens, positive ions flow into the cell, resulting in electrical impulses that enable the heart to beat. D
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