The dura mater as a reservoir and entry point for IgA+ plasma cells into the brain during inflammation

硬脑膜是炎症期间 IgA 浆细胞进入大脑的储存库和入口点

• 批准号: 437166
• 负责人: Florescu Alexandra
• 金额: $ 10.93万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-11-01 至 2023-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=437166&lang=en
• 关键词: Experimental Autoimmune Encephalomyelitis; Human Cytokine And Chemokine Luminex Panel; Human Tissue; Immunofluorescence; Live 2 Photon Laser Scanning Microscopy; Mass Cytometry; Meninges; Multiple Sclerosis

Multiple sclerosis (MS) is a disease of the brain and spinal cord in which the protective covering of nerves is destroyed by immune cells that cause inflammation. We have found that anti-inflammatory cells that originate in the small intestine can migrate

多发性硬化症 (MS) 是一种大脑和脊髓疾病，其中神经的保护层被导致炎症的免疫细胞破坏。我们发现源自小肠的抗炎细胞可以迁移