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Adapting DNA-guided base editors to evaluate the effects of mitochondrial DNA variant (m.4917A>G) in bipolar disorder patient-derived cortical neurons

Adapting DNA-guided base editors to evaluate the effects of mitochondrial DNA variant (m.4917A>G) in bipolar disorder patient-derived cortical neurons
采用 DNA 引导碱基编辑器评估线粒体 DNA 变异 (m.4917A>G) 对双相情感障碍患者来源的皮质神经元的影响
批准号:
473523
负责人:
Mendes-Silva Ana P
金额:
$9.83万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-10-01 至 2025-10-01

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Mitochondria are cellular organelles responsible for generating energy for human cells. The more energetically demanding a cell is, such as neurons, the more critical the health of mitochondria is. People with bipolar disorder experience mitochondrial de
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