Calcium Imaging of Tactile Sensory Processing Dysfunction in a Mouse Model of Rett Syndrome

雷特综合征小鼠模型触觉感觉处理功能障碍的钙成像

• 批准号: 486284
• 负责人: Kaban Taylor L
• 金额: $ 1.27万
• 依托单位: University of Victoria (British Columbia)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486284&lang=en
• 关键词: In Vivo Calcium Imaging; Intrinsic Optical Signaling Imaging; Mouse Model; Neurodevelopmental Disorder; Rett Syndrome; Sensory Adaptation; Somatosensory System; Synaptic Plasticity; Tactile Sensory Processing; Two-Photon Microscopy

This project investigates sensory processing dysfunction in a mouse model of Rett Syndrome (RTT). RTT is a neurodevelopmental disorder with complex symptoms that culminate in requiring full-time care. RTT is caused by mutations to a gene called MECP2 that

本研究以Rett症候群（RTT）小鼠为研究对象，探讨感觉处理功能障碍。RTT是一种神经发育障碍，具有复杂的症状，最终需要全职护理。RTT是由一种名为MECP2的基因突变引起的，