The role of p66Shc in reactive oxygen species (ROS)-mediated cellular senescence.

p66Shc 在活性氧 (ROS) 介导的细胞衰老中的作用。

• 批准号: 199804
• 负责人: Hunt Andrea
• 金额: $ 1.27万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-02-01 至 2011-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=199804&lang=en
• 关键词: Apoptosis; Mitochondrial Permeability Transition Pores; Oxidative Stress; P66shc; Reactive Oxygen Species; Senescence

Currently, one of the most accepted theories of aging is the free-radical hypothesis, which states that mammals are constantly being exposed to harmful reactive oxygen species (ROS), either produced by innate cellular mechanisms or come across in the envi

目前，最被接受的衰老理论之一是自由基假说，该假说认为哺乳动物不断暴露于有害的活性氧（ROS），这些活性氧要么是由先天细胞机制产生的，要么是在环境中遇到的。