Investigating the sex-dependent influence of commensal microbiota on invariant Natural Killer cell-mediated immunity in a type I diabetes mouse model

在 I 型糖尿病小鼠模型中研究共生微生物群对恒定自然杀伤细胞介导的免疫的性别依赖性影响

• 批准号: 311833
• 负责人: Serkis Viktoria
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-12-01 至 2014-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=311833&lang=en
• 关键词: Autoimmunity; Invariant Natural Killer Cells; Microbiome; Type 1 Diabetes

Background Many autoimmune diseases, including type 1 diabetes (T1D), are described to follow a similar general scheme: (1) possession of a high risk genetic background, coupled with a gender-bias favouring females and environmental factors (2) immune dy

背景 许多自身免疫性疾病，包括1型糖尿病（T1 D），都被描述为遵循类似的一般方案：（1）拥有高风险遗传背景，加上有利于女性的性别偏见和环境因素（2）免疫缺陷