Elucidating the Molecular Mechanisms of the Novel Anti-Convulsant Retigabine Using Voltage Clamp Fluorimetry and Unnatural Amino Acid Mutagenesis

使用电压钳荧光法和非天然氨基酸诱变阐明新型抗惊厥药瑞替加滨的分子机制

• 批准号: 312033
• 负责人: Kim Robin Y
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-12-01 至 2014-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=312033&lang=en
• 关键词: Anti-Convulsant; Electrophysiology; Epilepsy; Ion Channels; Mechanisms; Neuroscience; Pharmacology; Treatment; Two Electrode Voltage Clamping; Unnatural Amino Acids

Epilepsy encompasses a diverse set of neurological conditions characterized by frequent seizures due to abnormal and excessive electrical activity in the brain. Despite the availability of over 20 drugs on the market for the management of epileptic seizur

癫痫包括一组不同的神经状况，其特征是由于大脑中异常和过度的电活动而频繁发作。尽管市场上有20多种治疗癫痫发作的药物