The combinational effects and functional mechanism of VR23 and ionizing radiation

VR23与电离辐射的联合作用及作用机制

• 批准号: 311984
• 负责人: Soleimani FATEMEH
• 金额: $ 1.27万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-12-01 至 2014-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=311984&lang=en
• 关键词: Combinational Therapy; Molecular Mechanisms; Radiation; Vr23

VR23, an anti-cancer compound as a proteasome inhibitor has different sites of action in cancer cells, like NFkB, cell cycle, regulation of apoptosis, p53… through many of these mechanisms cancer cells could be more sensitive to the effects of radiotherap

VR23是一种抗癌化合物，作为蛋白酶体抑制剂，在癌细胞中具有不同的作用位点，如NFkB、细胞周期、细胞凋亡调节、p53……通过许多这些机制，癌细胞可能对放射治疗的效果更敏感