Genetic instability of the haploid male germ cells

单倍体雄性生殖细胞的遗传不稳定性

• 批准号: 304389
• 负责人: Boissonneault Guylain
• 金额: $ 24.96万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-03-01 至 2017-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=304389&lang=en
• 关键词: Dna Breaks; Dna Repair; Evolution; Genetic Diseases; Genetic Instability; Huntington Disease; Mutation; Non-Homologous End-Joining; Polymorphism; Spermiogenesis

Genetic diversity is provided by de novo transmittable mutations and it is now known that most new mutations are male- driven. During the formation of spermatozoa, the final steps involves a major change in the way DNA is packaged and we demonstrated that

遗传多样性是由从头开始的可传播突变提供的，现在已知大多数新的突变是男性驱动的。在精子的形成过程中，最后的步骤涉及DNA包装方式的重大变化，我们证明，