Presidential Young Investigator Award/Development of New Organic Synthetic Reactions

总统青年研究员奖/新有机合成反应的发展

• 批准号: 8657016
• 负责人: Ken Feldman
• 金额: $ 31.2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8657016&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Development

Dr. Ken Feldman is a new awardee under the Presidential Young Investigators Program, with interests in synthetic organic chemistry. Dr. Feldman's experience was enriched with a stay in industry before joining the staff at the Pennsylvania State University. The emphasis of the research is on the development of novel bond-forming processes useful for the synthesis of complex natural products. The research involves two projects, both of which are designed to effect a multicomponent condensation of a finite and predetermined number of small "monomer" units. By this methodology, one can efficiently construct a complex organic structure from simple precursors. Both projects utilize reaction sequences which include initiation, propagation, and termination stages. By precisely controlling the timing of these three events, one can control the length of the propagation portion of the sequence and hence control the overall number of "monomer" units which are incorporated in the product molecule. Ultimately, these "oligomeric" segments will be useful in the synthesis of natural products which themselves have small segments of repeating molecular units, such as the polyacetate-derived polyene antibiotics.

肯·费尔德曼博士是总统青年研究员计划的新获奖者，对合成有机化学感兴趣。 在加入宾夕法尼亚州立大学之前，费尔德曼博士在工业界的工作经历丰富了他的经验。 该研究的重点是开发可用于合成复杂天然产物的新型成键工艺。 该研究涉及两个项目，这两个项目都旨在实现有限且预定数量的小“单体”单元的多组分缩合。 通过这种方法，人们可以从简单的前体有效地构建复杂的有机结构。 这两个项目都利用反应序列，包括引发、传播和终止阶段。 通过精确控制这三个事件的时间，可以控制序列的增殖部分的长度，从而控制掺入产物分子中的“单体”单元的总数。 最终，这些“寡聚”片段将可用于合成天然产物，这些天然产物本身具有重复分子单元的小片段，例如聚乙酸酯衍生的多烯抗生素。