Assembly of the Anthrax Toxin Protein Translocase

炭疽毒素蛋白转位酶的组装

• 批准号: 303479
• 负责人: Mogridge Jeremy
• 金额: $ 47.99万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-03-01 至 2019-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=303479&lang=en
• 关键词: Anthrax; Bacterial Toxin; Membrane Protein; Translocase

Anthrax toxin is comprised of two toxic enzymes and a third protein, PA, which assembles into a nanomachine that delivers the toxic enzymes to the interior of human cells. We are studying two critical steps in the assembly of this translocation machine.

炭疽毒素由两种有毒的酶和第三种蛋白质PA组成，PA组装成一台纳米机器，将有毒的酶输送到人类细胞内部。我们正在研究组装这台移位机的两个关键步骤。