Model Studies of Molecular Interactions in Biomembranes

生物膜分子相互作用的模型研究

• 批准号: 8703644
• 负责人: Hugh Scott
• 金额: $ 14.8万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8703644&HistoricalAwards=false
• 关键词: Model; Studies; Molecular; Interactions; Biomembranes

Biomembrane physics has been subject to a tremendous development during the last decade. This is due to experimentors who, using techniques from modern physics, have provided an accurate experimental description of certain synthetic lipid bilayers and reconstituted cell membranes. As a result of the experimental efforts, these model membranes now present themselves as extremely well- characterized systems with properties which are believed to be common to a great variety of biological membranes. At the same time, the experimental work has highlighted an urgent need for a parallel theoretical actiity. Dr. Scott's research addresses questions involving the nature and manifestiation of molecular interactions in biomembranes. The first is an analytical project in which new models for lipid bilayer condensed phases will be constructed and analyzed. The second is a large scale simulation of model lipid-protein interactions in membranes. Statistical physics is a difficult field to work in and more so when combined with biology. Dr. Scott's recent record demonstrates that he is most capable of handling any problems that arise and will make significant contributions to this field.

生物膜物理学在过去的十年中得到了巨大的发展。这归功于实验人员，他们使用现代物理学的技术，提供了对某些合成类脂双层和重组细胞膜的准确实验描述。作为实验努力的结果，这些模型膜现在呈现出极好的特性系统，其特性被认为是各种生物膜的共同特性。与此同时，实验工作突显了对平行理论活动的迫切需要。斯科特博士的研究涉及生物膜中分子相互作用的性质和表现形式。第一个是一个分析项目，在这个项目中，将构建和分析脂双层凝聚相的新模型。第二个是对膜中模型脂-蛋白质相互作用的大规模模拟。统计物理学是一个很难研究的领域，当与生物学结合时更是如此。斯科特博士最近的记录表明，他最有能力处理出现的任何问题，并将为这一领域做出重大贡献。