Optimizing the size and composition of beta cell aggregates to improve islet graft survival

优化 β 细胞聚集体的大小和组成以提高胰岛移植物的存活率

• 批准号: 304249
• 负责人: Ungrin Mark D
• 金额: $ 42.73万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-03-01 至 2019-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=304249&lang=en
• 关键词: Cell Survival; Controlled Cellular Aggregation; Extracellular Matrix; Islet Transplantation; Metabolic Transport Processes; Mixed Cellular Aggregates; Oxygenation; Retention Of Function; Size Control; Surface:Volume Ratio

In type I diabetes, patients lose most or all of the pancreatic beta cells that produce insulin, a hormone required to control blood sugar levels. While insulin can be provided via injection, this does not fully replace the real-time feedback control prov

在I型糖尿病中，患者失去了大部分或全部产生胰岛素的胰腺β细胞，胰岛素是控制血糖水平所需的激素。虽然胰岛素可以通过注射提供，但这并不能完全取代实时反馈控制prov。