Enzymology of DNA Repair, SFC Award in Pakistani and U.S. Currencies

DNA 修复酶学，巴基斯坦和美国货币 SFC 奖

• 批准号: 8713991
• 负责人: Lawrence Grossman
• 金额: $ 4.63万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-15 至 1991-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8713991&HistoricalAwards=false
• 关键词: Enzymology; DNA; Repair; SFC; Award

Description: This project is for research on the molecular mechanisms of cellular repair of alkylated DNA in M. Iuteus after its exposure to alkylating agents. The experiments will involve purification and characterization of enzymes which are seemingly specific to certain alkylating agents. Their structural chemistry will be studied in order to investigate the physiochemical interaction between repair proteins and DNA base adducts. These experiments will be carried out by Dr. A. Athar at the Center for Advanced Molecular Biology (CAMB) in Lahere, Pakistan. The laboratory of Dr. Lawrence Grossman at Johns Hopkins University will assist Pakistani collaborators in conducting those experiments that could not be done in Pakistan. Scope: The collaboration is beneficial to both institutions and is expected to yield information leading to better understanding of molecular mechanisms of cellular repair of alkylation damage to genetic material. The past work by the two laboratories has resulted in several joint publications.

项目描述：本项目是关于分子机制的研究 的细胞修复的烷基化DNA在M. Iuteus在暴露于 烷基化剂 实验将涉及纯化和 酶的特性似乎是特定于某些 烷基化剂 它们的结构化学将被研究， 研究修复蛋白之间的物理化学相互作用， 和DNA碱基加合物。 这些实验将由A博士进行。 Athar在Lahere的高级分子生物学中心（CAMB）， 巴基斯坦 约翰霍普金斯大学的劳伦斯·格罗斯曼博士的实验室 大学将协助巴基斯坦合作者进行这些 在巴基斯坦无法进行的实验。 范围：合作对两个机构都有利， 预期产生的信息将有助于更好地了解 细胞修复烷基化损伤的分子机制 材料 这两个实验室过去的工作导致了 几个联合出版物。