Joint U.S.-Italy Symposium on Protein Metabolism in Aging; Pisa, April 1989

该奖项将支持一组之间的合作研讨会， 以达雷尔·道尔和莫顿教授为首的美国研究人员 纽约州立大学布法罗分校的罗斯坦和一个类似的意大利小组 研究人员以教授E。Bergamini和P.L.伊帕塔 比萨大学关于衰老中蛋白质代谢的课题。 蛋白质代谢的改变代表了 老化过程 虽然众所周知， 然而，这些变化背后的机制并不明确。 为 例如，来自各种组织的无细胞蛋白质合成系统 老年动物的功能不如同等年龄的动物 具有高度显著差异的年轻制剂。 最近 研究表明，老年大鼠肝脏核糖体缺乏 存在于年轻核糖体中的蛋白质因子。 在更广泛的范围内， 已经显示蛋白质周转随年龄显著减慢， 虽然原因不明 酶结构的改变 随着年龄的增长，这是一个可以被认为会导致生理性 后果也。 激素受体的改变也会 有望在代谢调节中发挥调节作用。 这些是目前和正在进行的各种 与衰老和蛋白质变化有关的研究。 的目的 召开拟议的会议是为了增加我们对以下问题的了解： 我们对蛋白质结构、调节和代谢的了解， 它与衰老有关。 虽然还有其他与蛋白质周转有关的会议， 到目前为止，还没有人关注与年龄相关的蛋白质结构变化 和新陈代谢，以及重要的相关选定的主题， 地区 给美国老龄化人口这个话题是一个 对基础研究的兴趣越来越大。 一个工作坊聚在一起 美国的研究人员与意大利的领先研究人员合作， 对老龄化研究的强烈关注已经发展起来，有可能 从而成功地交流信息，并使今后 在这一重要领域的合作项目。

This award will support a collaborative workshop between a group of U.S. researchers headed by Professors Darrell Doyle and Morton Rothstein of SUNY at Buffalo, and a similar group of Italian researchers headed by Professors E. Bergamini and P. L. Ipata of the University of Pisa on the subject of protein metabolism in aging. Alterations of protein metabolism represent an important facet of the aging process. While it is known that a number of changes take place, the mechanisms behind these changes are poorly defined. For example, cell-free protein synthesizing systems from various tissues of old animals function less effectively than those from equivalent young preparations with highly significant differences. More recent work has demonstrated that old rat liver ribosomes are deficient in a protein factor present in young ribosomes. On a broader scale, protein turnover has been shown to slow substantially with age, although the reasons are obscure. Alterations in enzyme structure with age is an area that can be presumed to lead to physiological consequences also. Modifications of hormone receptors would also be expected to play a role in regulation of metabolism regulation. These are a few examples of a variety of current and ongoing investigations related to aging and protein changes. The purpose of convening the proposed meeting is to increase our understanding of what is known about protein structure, regulation, and metabolism as it relates to aging. While there have been other meetings related to protein turnover, none so far has focused on age-related changes in protein structure and metabolism, together with selected topics in important related areas. Giving the aging population in the U.S. this topic is one of increasing interest for basic research. A workshop getting together researchers in the U.S. with leading researchers in Italy, where a strong focus on aging research has developed, has the potential to lead to successful exchange of information and to future collaborative projects in this important area.