Neutron Scattering Analysis of Biological Structures: An External Users Program

中子散射的使用特别适合于 蛋白质-核酸复合物和膜的分析， 中子散射的相对较大的差异， 氢和氘。 这种差异使得很容易 区分氘标记的蛋白质和未标记的蛋白质， 脂质和核酸。 在蛋白质晶体学中，中子 显示氢和/或氘原子的存在， 复杂的氢键 氢氘交换研究 提供蛋白质结构的动力学性质的信息 并提供具体电荷转移的详细说明 机制等 布鲁克海文中子散射设施提供三个 带有二维探测器的自动数据采集系统， 蛋白质晶体学、膜衍射和小角衍射 散布在美国各地供生物学家使用。 该设施还提供技术和科学人员， 设施的有效运行和维护， 以及提供“生物中子”专业知识， 不熟悉中子散射技术的用户。

The use of neutron scattering is particularly suited for the analysis of protein-nucleic acid complexes and membranes because of the relatively large difference in neutron scattering between hydrogen and deuterium. This difference makes it easy to distinguish deuterium labeled proteins from unlabeled proteins, lipids and nucleic acids. In protein crystallography, neutrons reveal the presence of hydrogen and/or deuterium atoms with their intricate hydrogen bonding. Hydrogen-deuterium exchange studies provide information on dynamic properties of protein structures and provide detailed description of specific charge transfer mechanisms. The Brookhaven Neutron Scattering Facilities provides three automatic data acquisition systems with 2D detectors for protein crystallography, membrane diffraction and small angle scattering for the use of biologists through the U.S. The facility also provides technical and scientific staff for efficient running and maintenance of the facilities, as well as provision of "biological neutron" expertise for users unfamiliar with neutron scattering techniques.