Sex-specific functional and transcriptional contributions of the cortico-striatal and -tegmental pathways in mediating stress susceptibility and resilience

皮质纹状体和被盖通路在调节应激敏感性和恢复力中的性别特异性功能和转录贡献

• 批准号: 377727
• 负责人: Labont Benoit
• 金额: $ 10.93万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-11-01 至 2019-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=377727&lang=en
• 关键词: Bioinformatics; Cell Type-Specific Investigation; Medial Prefrontal Cortex; Mouse Model Of Stress; Neuronal Circuits; Sex-Specific Investigation; Stress-Induced Mood Disorders; Transcriptomics; Viral-Mediated Gene Transfer

Major depressive disorder (MDD) is a sexually dimorphic condition affecting millions of men and women every year. Despite its highly heterogeneous aetiology, chronic stress is a recurring factor interfering with the establishment of cognitive strategies r

严重抑郁障碍(MDD)是一种性两面性疾病，每年影响数百万男性和女性。尽管慢性应激具有高度的异质性，但它是干扰认知策略建立的一个反复出现的因素。