Molecular and functional studies of ENT proteins: towards an understanding of their role in cancer therapeutics.

耳鼻喉科蛋白的分子和功能研究：了解它们在癌症治疗中的作用。

• 批准号: 170762
• 负责人: Young James D
• 金额: $ 54.73万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170762&lang=en
• 关键词: Cancer Therapeutics; Membrane Protein Biochemistry; Membrane Transporters; Nucleoside Drugs; Nucleoside Transport; Recombinant Dna Technology

A number of nucleoside analogs have anticancer activities and are either in current clinical use or in various stages of preclinical evaluation. Since the pharmacological targets of nucleoside drugs are intracellular, penetration of cells by passage acro

许多核苷类似物具有抗癌活性，并且在当前的临床使用中或在临床前评价的各个阶段中。 由于核苷类药物的药理学作用靶点是细胞内，因此通过跨膜途径穿透细胞，