Molecular and cellular studies of novel subtilase-directed secretory pathway serpins

新型枯草杆菌酶定向分泌途径丝氨酸蛋白酶抑制剂的分子和细胞研究

• 批准号: 178316
• 负责人: Jean François
• 金额: $ 7.29万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2009-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=178316&lang=en
• 关键词: Cell Biology; Host Cell Proprotein Convertases; Molecular Virology; Secretory Pathway Furin-Like Enzymes; Secretory Pathway Serine Protease Inhibitors; Serine Protease Inhibitor (Serpin)

Current antiviral therapeutic strategies target viral gene products. Although initially successful, the usefulness of these strategies is limited by their severe toxicity and susceptibility to circumvention by drug-resistant variants. In contrast, because

目前的抗病毒治疗策略靶向病毒基因产物。虽然最初是成功的，但这些策略的有效性受到其严重毒性和对耐药变异体规避的敏感性的限制。相比之下，因为