Electrophilic Substitution of Aryltrimethylsilanes (Chemistry)

这是一项妇女研究机会倡议(ROW)的研究计划补助金(RPG)，该倡议由化学部有机和高分子化学计划提供。它将为斯克兰顿大学的琳达·A·雅各布博士提供资源和时间来制定研究计划。芳基三甲基硅烷的亲电取代将作为一种制备含磷或含氟芳香氨基酸的方法进行研究。最初的重点将是更简单的结构，如F-18标记的多肽，可能会在无线电成像中使用，或者在适当的情况下与磁性成像技术一起使用。后一方面将与纽约大学医学院的科学家合作进行。

This is a Research Planning Grant (RPG) of the Research Opportunities for Women Initiative (ROW) that is being made by the Organic and Macromolecular Chemistry Program of the Chemistry Division. It will provide Dr. Linda A. Jacob of the University of Scranton with resources and time to develop a research program. The electrophilic substitution of aryltrimethylsilanes will be studied as a method for preparing phosphorous or fluorine containing aromatic amino acids. The initial focus will be on simpler structures such as F-18 labelled peptides that might find use in radio imaging or where appropriate with magnetic imaging techniques. The latter aspects will be carried out cooperatively with scientists at New York University Medical School.