Electrophilic Substitution of Aryltrimethylsilanes (Chemistry)

芳基三甲基硅烷的亲电取代（化学）

• 批准号: 8808455
• 负责人: Linda Jacob
• 金额: --
• 依托单位: University of Scranton
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8808455&HistoricalAwards=false
• 关键词: Electrophilic; Substitution; Aryltrimethylsilanes; Chemistry

This is a Research Planning Grant (RPG) of the Research Opportunities for Women Initiative (ROW) that is being made by the Organic and Macromolecular Chemistry Program of the Chemistry Division. It will provide Dr. Linda A. Jacob of the University of Scranton with resources and time to develop a research program. The electrophilic substitution of aryltrimethylsilanes will be studied as a method for preparing phosphorous or fluorine containing aromatic amino acids. The initial focus will be on simpler structures such as F-18 labelled peptides that might find use in radio imaging or where appropriate with magnetic imaging techniques. The latter aspects will be carried out cooperatively with scientists at New York University Medical School.

这是女性研究机会倡议（ROW）的研究规划补助金（RPG），由化学部门的有机和高分子化学项目提供。 它将为斯克兰顿大学的 Linda A. Jacob 博士提供开发研究项目的资源和时间。 将研究芳基三甲基硅烷的亲电取代作为制备含磷或含氟芳香族氨基酸的方法。 最初的重点将放在更简单的结构上，例如 F-18 标记的肽，这些肽可能会用于无线电成像或适当的磁成像技术。 后者方面将与纽约大学医学院的科学家合作进行。