Expedited Award for Aqueous 2-Phase Extraction
Expedited Award for Aqueous 2-Phase Extraction
批准号:
8812343
负责人:
Stanley Sandler
金额:
$3.0万
依托单位:
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-04-01 至 1990-03-31
中文摘要
该研究的目的是开发一种新的方法,以最大限度地减少用于生物分离和生物纯化的水两相分配过程中昂贵的亲和配体的损失。具体的研究是在水两相体系中纯化蛋白质,该体系由葡聚糖、高分子量聚乙二醇(PEG)和附着的配体、以及牺牲的低分子量PEG,其与葡聚糖更相容,从而使连接的PEG在葡聚糖相中的损失最小化。配体的损失是生物分离和生物净化的水两相分配工艺商业化的主要障碍。该研究的成功将加速该分区的商业化进程。
英文摘要
The aim of the research is to develop a new method for minimizing the loss of the expensive affinity ligands used in aqueous two-phase partition processes for bioseparation and biopurification. The specific study is on the purification of a protein in an aqueous two-phase system consisting of dextran, a high molecular-weight polyethylene glycol (PEG) with attached ligand, and a sacrificial low molecular-weight PEG which is more compatible with dextran so it minimizes the loss of the ligated PEG into the dextran phase. Loss of ligands is a major impediment to the commercialization of the aqueous two-phase partitioning process for bioseparation and biopurification. Success of the research could accelerate the commercialization of the partition process.
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批准号:0853685
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项目类别:Standard Grant
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资助金额:$35.5万
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财政年份:2009
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负责人:Stanley Sandler
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依托单位:
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批准号:9521406
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项目类别:Continuing Grant
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资助金额:$34.5万
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财政年份:1996
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负责人:Stanley Sandler
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依托单位:
Second International Symposium on Thermodynamics in Chemical Engineering and Industry, Beijing, China, May 24-27, 1994
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批准号:9403799
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项目类别:Standard Grant
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资助金额:$2.46万
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财政年份:1994
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负责人:Stanley Sandler
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依托单位:
REU: Thermodynamics of Dilute Aqueous Solutions
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批准号:9123434
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项目类别:Continuing Grant
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资助金额:$26.7万
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财政年份:1992
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负责人:Stanley Sandler
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依托单位:
Research Equipment Grants: Analytical Equipment for Phase Equilibrium Research
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批准号:9112276
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项目类别:Standard Grant
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资助金额:$2.43万
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财政年份:1991
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负责人:Stanley Sandler
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依托单位:
Continuation of Vapor-Liquid Equilibrium for Chemical Engineering and Applied Thermodynamics: A Research Project with International Collaboration and Industrial Cooperation
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批准号:8914299
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项目类别:Continuing Grant
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资助金额:$15.56万
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财政年份:1989
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负责人:Stanley Sandler
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依托单位:
Group Travel: Visits by European Thermodynamicists to the United States
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批准号:8800325
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项目类别:Standard Grant
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资助金额:$0.98万
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财政年份:1988
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负责人:Stanley Sandler
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依托单位:
Engineering Research Equipment Grant: Phase Equilibrium andMolecular Thermodynamics
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批准号:8807952
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项目类别:Standard Grant
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资助金额:$2.51万
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财政年份:1988
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负责人:Stanley Sandler
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依托单位:
Support of Conference "Chemical Engineering Education in a Changing Environment"
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批准号:8715115
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项目类别:Standard Grant
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资助金额:$3.14万
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财政年份:1987
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负责人:Stanley Sandler
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依托单位:
Vapor Liquid Equilibrium for Chemical Processes and Applied Thermodynamics: International Collaboration and Industrial Cooperation (REU Supplement)
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批准号:8612285
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项目类别:Continuing Grant
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资助金额:$14.43万
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财政年份:1986
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负责人:Stanley Sandler
-
依托单位:
Supercomputer Initiation: Engineering Supercomputer Initiation Grant
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批准号:8515811
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项目类别:Standard Grant
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资助金额:$0.0万
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财政年份:1985
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负责人:Stanley Sandler
-
依托单位:
International Cooperative Research Project on Vapor-Liquid Equilibrium For Chemical Engineering and Applied Thermo- Dynamics
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批准号:8316913
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项目类别:Standard Grant
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资助金额:$6.64万
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财政年份:1984
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负责人:Stanley Sandler
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依托单位:
Workshop: Thermodynamic Needs for the Decade Ahead: Theoryand Experiment; Washington, D.C.; October 28-29, 1983
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批准号:8319280
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项目类别:Standard Grant
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资助金额:$1.41万
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财政年份:1983
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负责人:Stanley Sandler
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依托单位:
Research Equipment For High Pressure Phase Equilibria
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批准号:8305153
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项目类别:Standard Grant
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资助金额:$1.79万
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财政年份:1983
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负责人:Stanley Sandler
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依托单位:
Specialized Research Equipment: Vapor-Liquid Equilibria ForSynthetic Fuels Processing
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批准号:8104553
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项目类别:Standard Grant
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资助金额:$0.85万
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财政年份:1981
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负责人:Stanley Sandler
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依托单位:
Collaborative Research: Gereralized Corresponding States Principal Using Two Nonspherical Reference Fluids
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批准号:8013756
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项目类别:Continuing Grant
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资助金额:$10.58万
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财政年份:1981
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负责人:Stanley Sandler
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依托单位:
The Use of the Plato System For Computer-Assisted Chemical Engineering Education
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批准号:7900084
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项目类别:Standard Grant
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资助金额:$2.5万
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负责人:Stanley Sandler
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依托单位:
海外基金