Developing Preclinical Optical Imaging Tools for Studying Vasculature, Microenvironment, and Radiation Response of Solid Tumours In Vivo.

开发用于研究体内实体瘤的脉管系统、微环境和辐射响应的临床前光学成像工具。

• 批准号: 252652
• 负责人: Dacosta Ralph S
• 金额: $ 32.62万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2016-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252652&lang=en
• 关键词: Genomic And Proteomic Profiling; Hypoxia And Oxygenation; Intravital Optical Molecular Imaging; Phosphorescence Lifetime Imaging; Photoacoustic Microscopic Imaging; Radiation Response; Spatio-Temporal Dynamics; Tumor Cell Death And Vascular Damage; Xenogr

Tumor vasculature and hypoxia (a lack of oxygen, O2) greatly influence tumor response to RT and both are attractive targets for improving response to therapy (e.g. new hypoxia-activated drugs are in clinical testing with RT to improve treatment outcome).

肿瘤血管系统和缺氧（缺氧，O2）极大地影响肿瘤对RT的反应，两者都是改善对治疗反应的有吸引力的靶点（例如，新的缺氧激活药物正在用RT进行临床试验，以改善治疗结果）。