Dissertation Research: Selective Neutrality of MitochondrialDNA Genotypes

论文研究：线粒体DNA基因型的选择性中性

• 批准号: 8815326
• 负责人: Thomas North
• 金额: $ 0.99万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1991-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8815326&HistoricalAwards=false
• 关键词: Dissertation; Research; Selective; Neutrality; MitochondrialDNA

Mitochondrial DNA (mtDNA) is an extra-nuclear, maternally inherited set of genes assumed to be selectively neutral; that is, their distribution within populations is subject only to chance events, and not to differences in evolutionary fitness conferred by these genes. The goal of this project is to detect effects, if any, of mitochondrial genes on an organism's morphology or nuclear genetic makeup. This is a first step towards understanding how mitochondrial and nuclear gene interactions may affect development, and , thus, how mtDNA genotypes may be subject to evolution by natural selection. Populations of wild trout, known to be hybrids between evolutionarily divergent groups, will be studied. Randomly mating hybrid swarms formed from such distinct taxa are rare in nature. They will permit statistical tests for association between mtDNA genotype and nuclear genotype, sex, and morphology (number of vertebrae, fluctuating asymmetry, etc.). Demonstration that mtDNA is subject to natural selection would have important implications for the widespread use of mtDNA as a marker for studies of genetic variation and population structure. Also, wild populations of trout are an important natural resource, the integrity of which is seriously threatened by hybridization with introduced species. This study will add to our understanding of the dynamics of interspecies hybridization in salmonid fishes.

线粒体DNA（mtDNA）是一种核外的、母系的DNA。 被认为是选择性中性的遗传基因组; 它们在人群中的分布只受 偶然事件，而不是进化适应性的差异 由这些基因决定的。 这个项目的目标是检测 如果有的话，线粒体基因对生物体的 形态学或核遗传组成。 这是第一步 了解线粒体和核基因 相互作用可能会影响发育，因此，线粒体DNA 基因型可以通过自然选择进行进化。 野生鳟鱼的种群，已知是杂交种， 进化上的分歧群体，将被研究。 随机 由这样不同的分类群形成的交配杂种群是罕见的， 自然 他们将允许统计测试协会 mtDNA基因型与核基因型、性别和形态之间的关系 （椎骨的数量、波动的不对称性等）。 证明mtDNA受自然选择的影响 将对线粒体DNA的广泛应用产生重要影响 作为遗传变异和种群研究的标记 结构 此外，野生种群的鳟鱼是一个重要的 自然资源的完整性受到严重威胁 通过与引进物种杂交。 这项研究将增加 我们对物种间杂交动力学的理解 在鲑科鱼类中。