Structure-Function Relationships in Biological System

生物系统中的结构-功能关系

• 批准号: 8816384
• 负责人: Chien Ho
• 金额: $ 61.26万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8816384&HistoricalAwards=false
• 关键词: Structure; Function; Relationships; Biological; System

Dr. Ho continues to study the molecular basis of transport processes in cell membranes by characterizing the molecular structures of and intermolecular interactions between individual membrane-associated components. The active transport of L- glutamine in membrane vesicles of E. Coli will be used as a model for investigating the essential processes in active transport, namely recognition, translocation, recovery and energy coupling. Techniques to be used include molecular genetics, X-ray crystallography and NMR. Cell membranes are the site of a large number of biological processes. Thus, knowledge of their molecular biology is one of the most important and active areas of research at the present time. An understanding of the molecular organization and dynamic interactions of the protein and lipid components of membranes is essential for a detailed description of a wide variety of normal and pathological cellular processes.

何博士继续研究运输的分子基础 细胞膜中的分子过程， 个体之间的结构和分子间相互作用 膜相关成分。 L-的主动转运 E.大肠杆菌将被用作模型 为了研究主动运输的基本过程， 即识别、转运、恢复和能量耦合。 将使用的技术包括分子遗传学，X射线 晶体学和NMR。 细胞膜是大量生物活性物质的聚集场所。 流程.因此，它们的分子生物学知识是 目前最重要和最活跃的研究领域 时间 对分子组织和动力学的理解 膜的蛋白质和脂质成分的相互作用是 详细描述各种正常的 和病理细胞过程。