Structure-Function Relationships in Biological System

何博士继续研究细胞膜转运过程的分子基础，通过表征单个膜相关成分的分子结构和分子间相互作用。L-谷氨酰胺在大肠杆菌膜泡中的主动转运将被用来研究主动转运中的基本过程，即识别、转位、恢复和能量耦合。使用的技术包括分子遗传学、X射线结晶学和核磁共振。细胞膜是大量生物过程的场所。因此，对它们的分子生物学知识是目前最重要和最活跃的研究领域之一。了解膜的蛋白质和脂类成分的分子组织和动态相互作用对于详细描述各种正常和病理的细胞过程是至关重要的。

Dr. Ho continues to study the molecular basis of transport processes in cell membranes by characterizing the molecular structures of and intermolecular interactions between individual membrane-associated components. The active transport of L- glutamine in membrane vesicles of E. Coli will be used as a model for investigating the essential processes in active transport, namely recognition, translocation, recovery and energy coupling. Techniques to be used include molecular genetics, X-ray crystallography and NMR. Cell membranes are the site of a large number of biological processes. Thus, knowledge of their molecular biology is one of the most important and active areas of research at the present time. An understanding of the molecular organization and dynamic interactions of the protein and lipid components of membranes is essential for a detailed description of a wide variety of normal and pathological cellular processes.