Reactive Intermediates and Reaction Mechanisms

反应中间体和反应机理

• 批准号: 8820073
• 负责人: Jerome Berson
• 金额: $ 53.46万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8820073&HistoricalAwards=false
• 关键词: Reactive; Intermediates; Reaction; Mechanisms

This grant, funded by the Organic Dynamics Program in Chemistry,provides support for the research of Dr. Jerome Berson at Yale University. The objective of the research is the preparation, isolation and characterization of often unstable intermediates formed in chemical reactions. The chemical and physical behaviour of the reactive intermediates will be correlated with theoretical calculations. The principal intermediates to be studied are biradicals, which Berson makes by innovative synthetic routes. He will isolate them using techniques such as low temperature matrix isolation and then measures their spectral properties. On warming he can observe the regiospecific dimerization and cyclization behaviour of the biradicals and correlate the results with theory. These studies enhance our fundamental understanding of how chemical reactions occur and should be useful along a broad front of chemical syntheses.

这项资助由化学有机动力学项目资助，为耶鲁大学Jerome Berson博士的研究提供支持。本研究的目的是制备、分离和表征在化学反应中形成的通常不稳定的中间体。反应中间体的化学和物理行为将与理论计算相关联。研究的主要中间体是双自由基，这是博森公司通过创新的合成路线制造的。他将使用低温矩阵分离等技术分离它们，然后测量它们的光谱特性。在加热时，他可以观察到双基的区域特异性二聚化和环化行为，并将结果与理论联系起来。这些研究增强了我们对化学反应如何发生的基本理解，并且应该在化学合成的广泛前沿有用。