Role of NMDA Receptors in the Development of Mammalian Visual Cortex

NMDA 受体在哺乳动物视觉皮层发育中的作用

• 批准号: 8820406
• 负责人: Michael Stryker
• 金额: $ 24.95万
• 依托单位: University of California-San Francisco
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-15 至 1993-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8820406&HistoricalAwards=false
• 关键词: Role; NMDA; Receptors; Development; Mammalian

Neural plasticity refers to the ability of central nervous system connections to be modified or rearranged, particularly during a critical period early in development. The overall goal of Dr. Stryker's research over the past several years has been to understand the role of neural activity in mammalian visual system plasticity and development. Much recent evidence from studies of long-term potentiation (LTP) in the hippocampus suggests that the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor plays a crucial role in this neural activity-dependent synaptic plasticity. LTP plasticity is found in both young and adult nervous systems. In this project, Dr. Stryker and his colleagues will conduct several studies to elucidate the role of NMDA receptors in mediating the effects of activity on the plasticity of the cat visual cortex. Plasticity in the visual cortex is only found during an early stage of development. The investigators will infuse NMDA-antagonists into the visual cortex; measure electrophysiologically the specificity of the receptor blockade so produced; record the effects of NMDA- receptor blockade on patterns of neural activity; and study physiologically and anatomically effects on plasticity in development. Dr. Stryker has a long history of making significant contributions to our knowledge of nervous system development. This new work promises to reveal whether the cellular and molecular details of plasticity in the adult central nervous system (LTP), now receiving enormous research attention, apply also to the rearrangement of neuronal connections in brain development.

神经可塑性是指中枢神经系统的可塑性 需要修改或重新安排的系统连接，特别是 在发育早期的关键时期。 总目标 斯特赖克博士在过去几年的研究中 了解神经活动在哺乳动物视觉系统中的作用 可塑性和发展。 最近的长时程增强研究证据表明， (LTP)表明N-甲基-D-天冬氨酸 谷氨酸受体（NMDA）亚型在这一过程中起着至关重要的作用。 神经活动依赖性突触可塑性。 LTP可塑性是 存在于年轻人和成年人的神经系统中。 在这个项目中， 斯特赖克博士和他的同事将进行几项研究， 阐明NMDA受体介导的作用， 对猫视觉皮层可塑性的影响。 可塑性 在视觉皮层中只发现于 发展研究人员将注入NMDA拮抗剂， 视觉皮层;电生理学测量;特异性 记录NMDA的作用， 受体阻滞剂对神经活动模式的影响; 生理学和解剖学上的影响， 发展 斯特赖克医生长期以来 对我们了解神经系统发育的贡献。 这项新工作有望揭示细胞和 成人中枢神经可塑性的分子细节 系统（LTP），现在受到巨大的研究关注，应用 也与大脑中神经元连接的重组有关 发展