Acquisition of an Amino Acid Analyzer

这项提案要求为夏威夷大学的生物技术-分子生物学仪器设施购买具有高度灵敏度的最先进的氨基酸分析仪提供资金。这一设施是为所有需要蛋白质测序、肽和寡核苷酸合成服务的大学教职员工共同使用的，并在“按服务收费”的基础上提供相关服务。然而，该设施目前缺乏现代氨基酸分析仪，教职员工对蛋白质成分数据的需求也没有得到满足。校园里唯一一台专用于一个实验室的氨基酸分析仪是Beckman 121MB，已经有11年的历史了。就敏感性而言，它已经过时，而且由于缺乏备件，维护起来越来越困难。由于夏威夷与世隔绝，在大陆进行这样的常规分析是不切实际的。缺乏氨基酸分析仪是一个重大缺陷，如果得到纠正，将大大提高核心设施的能力，为大学研究界提供大分子表征服务。

This proposal requests funding for the purchase of a state-of- the-art amino acid analyzer with a high degree of sensitivity for University of Hawaii's Biotechnology-Molecular Biology Instrumentation Facility. This facility has been assembled for the shared use of all University faculty who require services in protein sequencing, peptide and oligonucleotide synthesis and related services on a "fee-for-service" basis. However, the facility currently lacks a modern amino acid analyzer and the faculty's needs for protein compositional data have gone unmet. The only existing amino acid analyzer on campus, which is dedicated to one lab, is a Beckman 121 MB and is 11 years old. It is outdated in terms of sensitivity and is increasingly difficult to maintain for lack of spare parts. Having such routine analysis done on the mainland is unrealistic because of Hawaii's geographical isolation. The lack of an amino acid analyzer is a major deficiency which if corrected will significantly enhance the capacity of the core facility to provide services in macromolecular characterization for the University research community.