RUI: Vertebrate Forebrain Organization: Ray-Finned Fishes

前脑是脊椎动物大脑的一部分， 进化成精巧的大脑半球。 大约一半 所有的脊椎动物都是硬骨鱼，但我们所知甚少。 这个重要群体的前脑结构 这 该项目将澄清在神经元领域的身份， 大脑的两个主要前部，端脑和 多骨鱼类的间脑 解剖学研究将遵循四条途径。 第一章 某些化学标记物的分布将通过 抗体结合，以鉴定与 在其他脊椎动物的前脑中也进行了类似的研究。 2)前脑和其他脑之间的连接模式 区域将通过局部摄取和神经元转运来确定 某些示踪物质。 3)不寻常的发展 将对这些鱼的前脑进行分析，以更好地了解 某些结构的起源和对应关系 在其他脊椎动物中发现。 4)将在以下方面进行比较： 在进化上密切相关的鱼类，但 不同的生活方式和不同发育的感觉系统， 为了深入了解特定的功能意义， 前脑的区域。 这项工作将为 生理学和行为学研究， 了解脊椎动物的组织和进化 大脑，并揭示新的方面的形式和功能关系， 前脑 这对神经科学很重要， 不仅仅是感官、运动或神经科学， 对大脑建模者很重要。

The forebrain is the part of the brain of vertebrates that has evolved into the elaborate cerebral hemispheres. Roughly half of all vertebrate species are bony fishes, yet we know very little about the forebrain structure of this important group. This project will clarify the identity of the neuronal fields in the two major anterior parts of the brain, the telencephalon and diencephalon, in bony fishes. Anatomical studies will follow four lines of approach. 1) Distribution of certain chemical markers will be studied by antibody binding, to identify regions that are comparable to similarly studied regions in the forebrain of other vertebrates. 2) Patterns of connections between forebrain and other brain regions will be determined by local uptake and neuronal transport of certain tracer substances. 3) The unusual development of the forebrain in these fish will be analyzed to better understand the origins and correspondences of certain structures with those found in other vertebrates. 4) Comparisons will be made among fish species that are closely related evolutionarily, but have diverse lifestyles and differentially developed sensory systems, to gain insight into the functional significance of specific regions of the forebrain. This work will provide a morphological foundation for physiological and behavioral studies, lead to better understanding of the organization and evolution of the vertebrate brain, and reveal new aspects of form and functional relations in the forebrain. It will be important to neuroscience in general, beyond just sensory, motor, or neuroscience, and perhaps important to brain modelers.