Synaptotagmin XI, a regulator of cytokine secretion and phagocytosis, is targeted by leishmanolysin.

突触结合蛋白 XI 是细胞因子分泌和吞噬作用的调节剂，是利什曼菌溶血素的靶标。

• 批准号: 283798
• 负责人: Arango Duque Guillermo
• 金额: $ 5.1万
• 依托单位: INRS-Institut Armand-Frappier (Laval)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2014-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=283798&lang=en
• 关键词: Cytokine Secretion; Gp63 Metalloprotease; Innate Immunity; Leishmania-Macrophage Interactions; Macrophage Biology; Parasitology; Phagosome Maturation; Synaptotagmin Xi

Leishmania parasites are responsible for ~70000 deaths per year and can cause cutaneous, mucocutaneous, and fatal visceral illness. Although treatments exist, anti-Leishmania drugs are toxic and very expensive. Leishmania infects macrophages, which are ce

利什曼原虫每年造成约70000人死亡，并可引起皮肤、粘膜皮肤和致命的内脏疾病。虽然存在治疗方法，但抗利什曼原虫药物是有毒的，而且非常昂贵。利什曼原虫感染巨噬细胞，