The NLRP3 inflammasome: understanding the mechanism of burn-induced hypermetabolism

NLRP3 炎症小体：了解烧伤引起的代谢亢进的机制

• 批准号: 283848
• 负责人: Stanojcic Mile
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2015-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=283848&lang=en
• 关键词: Catecholamines; Glibenclamide; Hypermetabolism; Immunology; Metabolism; Nlrp3 Inflammasome; Propranolol; Severe-Burn; Stress-Induced Diabetes; Two-Hit Rodent Model

Severe burn injury is a catastrophic event that forces a victim to succumb to a life long battle of recovering both physically and psychologically. Overactive metabolic response is a well-established hallmark of severe burns, which includes insulin resist

严重烧伤是一种灾难性的事件，迫使受害者屈服于一生的身体和心理恢复斗争。过度活跃的代谢反应是严重烧伤的一个公认的特征，包括胰岛素抵抗