Electro and Magnetooptic Studies of Phospholipid Tubules

磷脂小管的电和磁光研究

• 批准号: 8822228
• 负责人: Charles Rosenblatt
• 金额: $ 21.56万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8822228&HistoricalAwards=false
• 关键词: Electro; Magnetooptic; Studies; Phospholipid; Tubules

Under appropriate conditions of temperature, concentration and pressure, phospholipids organize into a variety of interesting and potentially useful structures, including flat lamellae, elongated rodlike structures, and closed vesicles. These vesicles range in dimension from hundreds of angstroms to tens of microns and consist of bilayers separated by an aqueous medium. A new structure composed of a polymerizable diacetylenic phospholipid was recently discovered by a joint Naval Research Laboratory/Geo-Centers group. Below 39 C pieces of bilayer assemble into straight, hollow tubules in a form similar to a roll of aluminum foil. A number of magneto-and electrooptic experiments are planned with these materials. Cotton-Mouton measurements will be made on dilute suspensions of tubles in order to better understand the molecular orientation with the tubule. At higher concentrations, birefringence and light scattering will be used to determine the interparticle potential of tubules in suspension, both the short and long range parts. In addition, an attempt will be made to locate a liquid crystal nematic phase which, if successful, will be complemented with studies of the mechanical properties and possible non-linear optical response. Finally, a number of different studies will be made involving tubule manipulation.

在适当的温度、浓度和 在压力下，磷脂组织成各种有趣的， 潜在有用的结构，包括平板、细长的 杆状结构和封闭囊泡。 这些囊泡分布在 尺寸从几百埃到几十微米， 由水性介质分离的双层。 一个新的结构， 一种可聚合的二炔属磷脂最近被一个 联合海军研究实验室/地理中心小组。 低于39 C的零件 双层组装成直的，中空的小管， 一卷铝箔 一些磁光和电光 计划用这些材料进行实验。 科顿穆通 将对管的稀释悬浮液进行测量， 更好地理解微管的分子取向。 在 将使用更高的浓度、双折射和光散射 为了确定悬浮液中小管的颗粒间电位， 无论是短距离还是长距离。 此外，还将尝试 使其定位液晶微相，如果成功， 将补充机械性能的研究， 可能的非线性光学响应。 最后，一些不同的 将进行涉及小管操作的研究。