Role of the Gsb and ciD-Ce Genes in Fly Development

霍姆格伦博士正在研究 果蝇的部分，特别感兴趣的是 两个基因簇的功能，醋栗（gsb）和肘 中断优势细胞（ciD-Ce）。他希望确定 gsb、ciD和Ce基因在节段模式形成中的作用 通过研究它们的分子功能以及它们与 其他基因片段。在他的实验中，他将描述 ciD和Ce的组织和表达模式 制备gsb、ciD和Ce基因产物的抗体; 决定基因表达的层次结构， 节段内后部结构的形成;并研究 gsb、ciD和Ce基因的启动子区。通过完成 通过这些实验，他应该了解细胞是如何 节的后部与前部区分开 细胞 %%% 许多动物都是分节的。越来越多的证据表明 一些昆虫和脊椎动物的基因 分段共享同源性。对这些基因的研究 果蝇是由广泛的知识， 基因的一部分。获得的知识将最 可能具有更广泛的相关性。 %%%//

Dr. Holmgren is studying the process of pattern formation within segments of Drosophila, and is particularly interested in the function of two gene clusters, gooseberry (gsb) and cubitus interruptus Dominant-Cell (ciD-Ce). He hopes to determine the role of the gsb, ciD and Ce genes in segmental pattern formation by studying their molecular function and their relationship to other segmentation genes. In his experiments,he will characterize the organization and pattern of expression of the ciD and Ce genes; make antibodies to the gsb, ciD and Ce gene products; determine the hierarchy of gene expression that leads to the formation of posterior structures within segments; and study the promoter regions of the gsb, ciD and Ce genes. By completing these experiments, he should understand how cells in the posterior part of the segment are distinguished from anterior cells. %%% Many animals are segmented. There is increasing evidence that some of the insect and vertebrate genes which control segmentation share homologies. The study of these genes in Drosophila is enhanced and facilitated by the extensive knowledge of genetics in this organism. The knowledge gained will most likely have more general relevance. %%%//